The current study focuses on the biphasic soft tissue and aims to simulating its material and hemo-dynamic response. The blood-perfused tissue is considered as a dynamic poro-hyperelastic material with blood-filled voids. A biphasic formulation—effectively, a generalization of Darcy’s law---is utilized, treating the phases are occupying fractions of the same volume and existing momentum exchange between them. The conservation equations is discretized by the method of Smoothed Particle Hydrodynamics. Inflow conditions are obtained from a systemic cardiovascular model with regulatory response, automatically adapting to hemorrhage and other disturbances. Simulations of the mechanics under baseline conditions have been demonstrated here.